Prokaryotic DNA polymerase

There are 5 known Prokaryotic DNA polymerases:

Pol I: implicated in DNA repair; has 5'->3' polymerase activity, and both 3'->5' exonuclease activity (proofreading) and 5'->3' exonuclease activity (RNA primer removal).
Pol II: involved in repairing damaged DNA; has 3'->5' exonuclease activity.
Pol III: the main polymerase in bacteria (responsible for elongation); has 3'->5' exonuclease activity (proofreading).
Pol IV: a Y-family DNA polymerase.
Pol V: a Y-family DNA polymerase; participates in bypassing DNA damage.

2.7.1: OH acceptor	Hexo- · Gluco- · Fructo- (Hepatic) · Galacto- · Phosphofructo- (1, Liver, Muscle, Platelet, 2) · Riboflavin · Shikimate · Thymidine (ADP-thymidine) · NAD⁺ · Glycerol · Pantothenate · Mevalonate · Pyruvate · Deoxycytidine · PFP · Diacylglycerol · Phosphoinositide 3 (Class I PI 3, Class II PI 3) · Sphingosine · Glucose-1,6-bisphosphate synthase

2.7.2: COOH acceptor	Phosphoglycerate · Aspartate

2.7.3: N acceptor	Creatine

2.7.4: PO₄ acceptor	Phosphomevalonate · Adenylate · Nucleoside-diphosphate · Uridylate · Guanylate · Thiamine-diphosphate

2.7.6: diphosphotransferase
(P₂O₇)

Ribose-phosphate diphosphokinase · Thiamine diphosphokinase

2.7.7: nucleotidyltransferase
(PO₄-nucleoside)

Polymerase

DNA polymerase	DNA-directed DNA polymerase: DNA polymerase I · DNA polymerase II · DNA polymerase III holoenzyme RNA-directed DNA polymerase: Reverse transcriptase (Telomerase) DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase

RNA nucleotidyltransferase	RNA polymerase/DNA-directed RNA polymerase: RNA polymerase I · RNA polymerase II · RNA polymerase III · RNA polymerase IV · Primase · RNA-dependent RNA polymerase PNPase

Phosphorolytic
3' to 5' exoribonuclease

RNase PH · PNPase

Uridylyltransferase

Glucose-1-phosphate uridylyltransferase · Galactose-1-phosphate uridylyltransferase

Guanylyltransferase

mRNA capping enzyme

Other

Recombinase (Integrase) · Transposase

2.7.8: miscellaneous

Phosphatidyltransferases	CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase · CDP-diacylglycerol—serine O-phosphatidyltransferase · CDP-diacylglycerol—inositol 3-phosphatidyltransferase · CDP-diacylglycerol—choline O-phosphatidyltransferase

Glycosyl-1-phosphotransferase	N-acetylglucosamine-1-phosphate transferase

2.7.10-2.7.13: protein kinase
(PO₄; protein acceptor)

2.7.10: protein-tyrosine	see tyrosine kinases

2.7.11: protein-serine/threonine	see serine/threonine-specific protein kinases

2.7.12: protein-dual-specificity	see serine/threonine-specific protein kinases

2.7.13: protein-histidine	Protein-histidine pros-kinase · Protein-histidine tele-kinase · Histidine kinase

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

DNA replication (Prokaryotic, Eukaryotic)

Separation
and initiation

Prokaryotic (initiation)	Pre-replication complex Cdc6 Helicase (dnaA, dnaB, T7) · Primase (dnaG)

Eukaryotic (preparation in G1 phase)	Pre-replication complex: Origin recognition complex (ORC1, ORC2, ORC3, ORC4, ORC5, ORC6) · Minichromosome maintenance (MCM2 · MCM3 · MCM4 · MCM5 · MCM6 · MCM7) · CDC6 Licensing factor Autonomously replicating sequence Single-strand binding protein (SSBP2, SSBP3, SSBP4) RNase H (RNASEH1, RNASEH2A) Helicase: HFM1 Primase: PRIM1 · PRIM2

Both	Origin of replication/Ori/Replicon Replication fork (Lagging and leading strands) · Okazaki fragment · Primer

Replication

Prokaryotic (elongation)	DNA polymerase III holoenzyme (dnaC, dnaE, dnaH, dnaN, dnaQ, dnaT, dnaX) · Replisome · DNA ligase · DNA clamp · Topoisomerase (DNA gyrase) Prokaryotic DNA polymerase: DNA polymerase I (Klenow fragment)

Eukaryotic (synthesis in S phase)	Replication factor C (RFC1) · Flap endonuclease (FEN1) · Topoisomerase · Replication protein A (RPA1) Eukaryotic DNA polymerase: delta (POLD1, POLD2, POLD3, POLD4) DNA clamp (PCNA)

Both	Movement: Processivity · DNA ligase

Termination

Telomere: Telomerase (TERT, TERC, DKC1)

see also DNA replication and repair-deficiency disorder
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

Prokaryotic DNA polymerase

See also